≥ 3 prior therapies, including an IMiD, a proteasome inhibitor, and an anti-CD38 antibody
Refractory to last prior therapy
ECOG 0 or 1
No donor-specific antibodies
No bridging therapy allowed
Dose escalation: 40, 160, and 320 x 106 CAR+ cells
ALLO-647: 13 to 30 mg x 3 days
Fludarabine: 30 mg/m2/d x 3 days
Cyclophosphamide: 300 mg/m2/d x 3 days
Functional Always active
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.