Welcome to Overland.

Position:  iPSC Platform_Open-rank

Location: On-site in the San Francisco Bay area

Department: Cell Therapy Platform Research

Report to: Head of Cell Therapy Platform Research

Our Company
Founded in 2020, Overland Pharmaceuticals is establishing a leading cross-border platform company focused on advanced modalities through strategic partnering and in-house R&D. Seeded by Hillhouse Capital with access to the global innovation and biopharma ecosystem, Overland is building an initial oncology portfolio of first-in-class allogeneic cell therapies and ADC programs through strategic partnerships with Allogene and ADC Therapeutics. In particular, Overland is establishing GMP manufacturing facilities and expanding our cell therapy platform to focus on next-generation iPSC-based cell therapies to serve global patients.

We are seeking a highly motivated iPSC professional to join our research team. The successful candidate will play a key role in building an industry-leading iPSC platform to develop life-saving allogeneic cell therapies. Overland Pharmaceuticals offers boundless opportunities, supportive environment, competitive compensation and comprehensive benefits.

Essential Duties and Responsibilities

1. Human iPSC cell line development for cell therapy.
2. Human iPSC cell line characterization and genetic engineering.
3. Design and perform experiments; collect, analyze and present data to stake holders.
4. Maintain organized, detailed records to support internal documentation and regulatory filing.
5. Manage research lab operations, hire and mentor junior scientists.

Skills and Competencies

1. Feeder-free human iPSC culture maintenance, expansion, and banking.
2. Human iPSC characterization using flow cytometry, fluoresce microscopy, genotyping and qPCR assays.
3. Human iPSC single cell sorting and clonal expansion.
4. Human iPSC CRIPSR genome editing and CRISPR On/Off-target analysis
5. iPSC lentivirus transduction and integrations site analysis using LM-PCR and NGS.
6. iPSC differentiation into hematological lineages, such as T and NK cells.
7. Understanding of allogeneic CAR-T and CAR-NK cell therapies.
8. Proficiency in designing, implementing, and troubleshooting flow cytometric experiments.
9. Practical experience in iPSC reprogramming from PBMC or isolated immune cells.
10. Experience iPSC related work under cGMP condition is preferred.
11. Able to work independently as well as in a team with diverse background.
12. Collect, analyze and present data to internal teams and external audiences.
13. Analyze, interpret and present scientific literature. Strong written and verbal communication skills.
14. A can-do attitude and an ability to adapt to evolving priorities. Able to travel when needed.

Educational Requirement

1. PhD/MS/MEng in Cell Biology, Bioengineering, Immunology or related field. Title and compensation commensurate with skills, achievements, experience and education.

Position: iPSC Engineering_Open-rank

Location: On-site in the San Francisco Bay area

Department: Cell Therapy Platform Research

Report to: Head of Cell Therapy Platform Research

Our Company
Founded in 2020, Overland Pharmaceuticals is establishing a leading cross-border platform company focused on advanced modalities through strategic partnering and in-house R&D. Seeded by Hillhouse Capital with access to the global innovation and biopharma ecosystem, Overland is building an initial oncology portfolio of first-in-class allogeneic cell therapies and ADC programs through strategic partnerships with Allogene and ADC Therapeutics. In particular, Overland is establishing GMP manufacturing facilities and expanding our cell therapy platform to focus on next-generation iPSC-based cell therapies to serve global patients.

We are seeking a highly motivated iPSC professional to join our research team. The successful candidate will play a key role in building an industry-leading iPSC platform to develop life-saving allogeneic cell therapies. Overland Pharmaceuticals offers boundless opportunities, supportive environment, competitive compensation and comprehensive benefits.

Essential Duties and Responsibilities

1. Human iPSC culture, genetic engineering, single cell sorting, clonal expansion and characterization.
2. Gene editing On/Off-target analysis and viral vector integration analysis.
3. Design and perform experiments; collect, analyze and present data to stake holders.
4. Maintain organized, detailed records to support internal documentation and regulatory filing.
5. Manage research lab operations, hire and mentor junior scientists.

Skills and Competencies

1. Feeder-free human iPSC culture maintenance, expansion, and banking.
2. Human iPSC precision genome editing using CRIPSR, TALEN, ZFN, Meganuclease or other methods.
3. Genome editing On/Off-target analysis using PCR, qPCR, digital PCR and NGS.
4. iPSC engineering using lentivirus, retrovirus or transposase.
5. Viral vector or transposon integration site analysis using LM-PCR and NGS analysis.
6. Human iPSC single cell sorting and clonal expansion.
7. Human iPSC characterization using flow cytometry, fluoresce microscopy, genotyping and qPCR assays.
8. Understanding of allogeneic CAR-T and CAR-NK cell therapies.
9. Proficiency in designing, implementing, and troubleshooting flow cytometric experiments.
10. Experience in iPSC and gene editing under cGMP condition is preferred.
11. Able to work independently as well as in a team with diverse background.
12. Collect, analyze and present data to internal teams and external audiences.
13. Analyze, interpret and present scientific literature. Strong written and verbal communication skills.
14. A can-do attitude and an ability to adapt to evolving priorities. Able to travel when needed.

Educational Requirement

1. PhD/MS/MEng in Cell Biology, Bioengineering, Immunology or related field. Title and compensation commensurate with skills, achievements, experience and education.

Position: iPSC Differentiation_Open-rank

Location: On-site in the San Francisco Bay area

Department: Cell Therapy Platform Research

Report to: Head of Cell Therapy Platform Research

Our Company
Founded in 2020, Overland Pharmaceuticals is establishing a leading cross-border platform company focused on advanced modalities through strategic partnering and in-house R&D. Seeded by Hillhouse Capital with access to the global innovation and biopharma ecosystem, Overland is building an initial oncology portfolio of first-in-class allogeneic cell therapies and ADC programs through strategic partnerships with Allogene and ADC Therapeutics. In particular, Overland is establishing GMP manufacturing facilities and expanding our cell therapy platform to focus on next-generation iPSC-based cell therapies to serve global patients.

We are seeking a highly motivated iPSC professional to join our research team. The successful candidate will play a key role in building an industry-leading iPSC platform to develop life-saving allogeneic cell therapies. Overland Pharmaceuticals offers boundless opportunities, supportive environment, competitive compensation and comprehensive benefits.

Essential Duties and Responsibilities

1. Feeder-free iPSC culture and differentiation into hematological lineages.
2. Ex vivo and In vivo Characterization of iPSC derived immune cells.
3. Design and perform experiments; collect, analyze and present data to stake holders.
4. Maintain organized, detailed records to support internal documentation and regulatory filing.
5. Manage research lab operations, hire and mentor junior scientists.

Skills and Competencies

1. Feeder-free human iPSC culture maintenance and expansion.
2. iPSC differentiation into immune cells, particularly ab T cells, γδ T cells, NK cells or related cell types.
3. Ex vivo and In vivo characterization iPSC-derived immune cells.
4. High through-put screening for iPSC differentiation conditions.
5. Cell linage tracing during differentiation using Single Cell RNA seq.
6. Expertise in HSC differentiation, T/NK cell development and fate determination.
7. Design, implement, and troubleshoot multi-color flow cytometric experiments.
8. Understanding of allogeneic CAR-T and CAR-NK cell therapies.
9. Experience in iPSC differentiation and immune cell therapy under cGMP condition is preferred.
10. Able to work independently as well as in a team with diverse background.
11. Collect, analyze and present data to internal teams and external audiences.
12. Analyze, interpret and present scientific literature. Strong written and verbal communication skills.
13. A can-do attitude and an ability to adapt to evolving priorities. Able to travel when needed.

Educational Requirement

1. PhD/MS/MEng in Immunology, Cell Biology, Biochemistry, Bioengineering related field. Title and compensation commensurate with skills, achievements, experience and education.

Position: Immune Cell Therapy_Open-rank

Location: On-site in the San Francisco Bay area

Department: Cell Therapy Platform Research

Report to: Head of Cell Therapy Platform Research

Our Company
Founded in 2020, Overland Pharmaceuticals is establishing a leading cross-border platform company focused on advanced modalities through strategic partnering and in-house R&D. Seeded by Hillhouse Capital with access to the global innovation and biopharma ecosystem, Overland is building an initial oncology portfolio of first-in-class allogeneic cell therapies and ADC programs through strategic partnerships with Allogene and ADC Therapeutics. In particular, Overland is establishing GMP manufacturing facilities and expanding our cell therapy platform to focus on next-generation iPSC-based cell therapies to serve global patients.

We are seeking a highly motivated immune cell therapy professional to join our research team. The successful candidate will play a key role in building an industry-leading iPSC platform to develop life-saving allogeneic cell therapies. Overland Pharmaceuticals offers boundless opportunities, supportive environment, competitive compensation and comprehensive benefits.

Essential Duties and Responsibilities

1. Serve as internal immunology expert to develop allogeneic immune cell therapies.
2. Develop phenotypic and functional assays for analysis of donor and iPSC-derived NK and T cells.
3. Develop reagents and assays to support CAR binder generation and characterization.
4. Design and perform experiments; collect, analyze and present data to stake holders.
5. Maintain organized, detailed records to support internal documentation and regulatory filing.
6. Manage research lab operations, hire and mentor junior scientists.

Skills and Competencies

1. Must have hands-on experience with human immune cell isolation, phenotypic and functional analysis.
2. Experience in Ex vivo NK or T activation, viral transduction and expansion is required.
3. Experience in Ex vivo NK or T killing assays is required. Experience using Incucyte is preferred.
4. Experience in In vivo CAR-NK or CAR-T function assay using NSG mice is required.
5. Experience with allogeneic CAR-NK or CAR-T is required; γδ T cell experience is desirable.
6. Understanding of allogeneic CAR-T and CAR-NK cell therapies.
7. Design, implement, and troubleshoot multi-color flow cytometric experiments.
8. Knowledge HSC differentiation, linage specification, and T/NK cell development.
9. Experience in immune cell therapy under cGMP condition is preferred.
10. Able to work independently as well as in a team with diverse background.
11. Collect, analyze and present data to internal teams and external audiences.
12. Analyze, interpret and present scientific literature. Strong written and verbal communication skills.
13. A can-do attitude and an ability to adapt to evolving priorities. Able to travel when needed.

Educational Requirement

1. PhD/MS/MEng in Immunology, Cell Biology, Biochemistry, Bioengineering related field. Title and compensation commensurate with skills, achievements, experience and education.