Scientist/Senior Scientist CAR-T

Position: Scientist/Senior Scientist CAR-T

Location: On-site in South San Francisco

Department: Cell Therapy Platform Research

Our Company
Founded in 2020, Overland Pharmaceuticals is a cross-border company focusing on advanced modalities through strategic partnering and in-house R&D. Seeded by Hillhouse Capital with access to the global innovation and biopharma ecosystem, Overland is building an oncology portfolio of first-in-class allogeneic cell therapies and ADC programs through strategic partnerships with Allogene and ADC Therapeutics. Overland has established GMP manufacturing facilities and is expanding our cell therapy platform to focus on CAR-T cell therapies to serve global patients.

Position Summary
We are seeking a highly motivated Scientist to join our CAR-T research team. The successful candidate will play a crucial role in the design, development, and optimization of chimeric antigen receptor (CAR) constructs using in vitro and in vivo assays. You will work closely with our cross-functional teams to advance our CAR-T candidates to clinical application.

Duties and Responsibilities

  1. CAR Design and Engineering:
    • Develop and optimize robust protocols to produce high-quality lentiviral vectors and CAR-T.
    • Design and construct combinational CAR libraries and perform NGS based screening.
    • Optimize CAR constructs to enhance CAR-T cell potency, persistence, and specificity.
  2. CAR-T Production, Characterization and Functional Assays:
    • Utilize IncuCyte, eSight, RTCA, and multicolor flow cytometry technologies to assess CAR-T cell phenotype, proliferation, cytotoxicity, and cytokine secretion.
    • Perform detailed phenotypic analysis of engineered CAR-T cell using multicolor flow cytometry.
    • Conduct preclinical studies to evaluate CAR-T cell efficacy and safety in relevant animal models.
  3. Data Analysis and Reporting:
    • Analyze experimental data, interpret results, and present findings to internal teams and management.
    • Prepare comprehensive reports and contribute to scientific publications and presentations.
  4. Team Leadership and Collaboration:
    • Collaborate with other scientists, foster a supportive and innovative work environment.
    • Collaborate with cross-functional teams, including immunologists, translational researchers, PD, and manufacturing scientists.

Requirements

  1. Demonstrated experience in CAR design and CAR-T production.
  2. Proficiency in functional assays, such as IncuCyte, eSight, RTCA, ELISA, MSD, and multicolor flow cytometry.
  3. Expertise in developing and utilizing in vivo mouse models for preclinical evaluation.
  4. Comprehensive understanding of immune-oncology and the principles of cellular therapies.
  5. A can-do attitude and an ability to adapt to evolving priorities in a startup setting.
  6. Able to work independently as well in a matrix team environment.
  7. Strong analytical and problem-solving skills, with a track record of protocol optimization and innovation.
  8. Excellent communication and leadership abilities, with the capability to inspire and mentor research teams.
  9. Maintain organized, detailed records to support internal documentation and regulatory requirements.
  10. Able to travel when needed.

Educational Requirement

  1. Ph.D. in Immunology, Molecular Biology, Cell Biology, or a related field with a strong focus on CAR-T research.

Overland Compensation and Benefits:

  1. The expected salary range for this position based in South San Francisco is $110,000~$155,000. The pay ultimately offered will be determined based on job-related qualifications, education, experience, and other job-related factors permitted by law.

Equal Employment Opportunity:

  1. Overland is an equal-opportunity employer and values diversity at our company. We do not discriminate based on race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Join our dedicated and passionate team, where you will have the opportunity to contribute to groundbreaking discoveries and make a significant impact on cancer patient outcomes. This position offers a stimulating and challenging work environment with opportunities for professional growth and career advancement.