Cell Engineering, Scientist/Senior Scientist

Position: Cell Engineering, Scientist/Senior Scientist

Location: On-site in the San Francisco Bay area

Department: Cell Therapy Platform Research

Our Company
Founded in 2020, Overland Pharmaceuticals is a cross-border platform company focusing on advanced modalities through strategic partnering and in-house R&D. Seeded by Hillhouse Capital with access to the global innovation and biopharma ecosystem, Overland is building an initial oncology portfolio of first-in-class allogeneic cell therapies and ADC programs through strategic partnerships with Allogene and ADC Therapeutics. Internally, Overland is establishing our cell therapy platform to focus on next-generation therapies to serve global patients.

We are seeking a highly motivated Cell Engineering Scientist/Senior Scientist to join our research team. The successful candidate will play a key role in building an industry-leading platform to develop life-saving allogeneic cell therapies. Overland Pharmaceuticals offers boundless opportunities, supportive environment, competitive compensation and comprehensive benefits.

Essential Duties and Responsibilities

  1. Design genetic engineering strategies for next-gen allogeneic cell therapies.
  2. Generate reagents and develop protocols for engineering of primary immune cells and iPSCs.
  3. Maintain detailed records to support internal research and regulatory filing.
  4. Work closely with Immune Cell Therapy and iPSC Cell Therapy groups to advance R&D programs.

Skills and Competencies

  1. Must have hands-on experience with genetic engineering of primary immune cells and/or iPSC.
  2. Strong molecular skills to design and clone viral vectors and produce viral particles.
  3. Genomic biology skills to design and generate guide RNAs and targeting vectors.
  4. Experience in CRISPR On/Off-target analysis using PCR, qPCR, ddPCR and NGS.
  5. Lentivirus transduction and integration site analysis using LM-PCR and NGS.
  6. Bioinformatics skills including single cell RNA sequencing data analysis is desirable.
  7. Proficiency in designing, implementing, and troubleshooting flow cytometric experiments is preferred.
  8. Practical experience in iPSC single cell sorting, clonal expansion and characterization is preferred.
  9. Able to work independently as well as in a team with diverse background.
  10. Able to collect, analyze and present data to the research and management teams.
  11. Strong written and verbal communication skills. CRIPSR related publication/patent is desirable.
  12. A can-do attitude and an ability to adapt to evolving priorities. Able to travel when needed.

Educational Requirement

  1. PhD in Molecular Biology, Biochemistry, Immunology, Cell Biology, Bioengineering, or related field.